Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 71, No. 7, 2007, pp.1503-1508
Published online, 18th May, 2007
DOI: 10.3987/COM-07-11071
The Nicotinic Acid-p-Aminophenylalanine-Hydroxybenzoic Acid Triads Induce Apoptosis in Human Leukemia U937 Cells

Mika Yamaguchi, Ryota Saito, Keiichiro Utsumi, Akira Ochiai, Norimichi Kawashima, Yoshikazu Tokuoka, and Akira Katoh*

*Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, Musashino-shi, Tokyo 180-8633, Japan

Abstract

The nicotinic acid-p-aminophenylalanine-hydroxybenzoic acid triads were newly synthesized from p-aminophenylalanine methyl ester via 4 steps, and they induced apoptosis in human leukemia U937 cells. The number of hydroxyl group on benzoic acid apparently affected upon the apoptosis-inducing activity.