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Note | Regular issue | Vol 71, No. 5, 2007, pp.1173-1181
Published online, 27th March, 2007
DOI: 10.3987/COM-07-11023
An Improved Synthesis of 3-Methyl-4-nitro-5-heteroarylethenylisoxazoles

Mauro F. A. Adamo,* Eleanor F. Duffy, Vivekananda R. Konda, and Finbar Murphy

*Department of Pharmaceutical and Medicinal Chemistry, Centre for Synthesis and Chemical Biology (CSCB), The Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Dublin, Ireland

Abstract

A high yielding synthesis of polyfunctional scaffold 3-methyl-4-nitro-5-heteroarylethenylisoxazole is described. The novel condition allowed the preparation of reactive title compounds in high yield.