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Paper | Regular issue | Vol 71, No. 5, 2007, pp.1107-1115
Published online, 27th March, 2007
DOI: 10.3987/COM-07-11014
Efficient Synthesis of Pyrimidinecarbonitriles and Their Derivatives

Petra Doláková, Milena Masojídková, and Antonín Holy*

*Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, CZ-16610 Prague 6, Czech Republic

Abstract

New approach to pyrimidinecarbonitriles was developed. Pyrimidine-4- and 6-carbonitriles were prepared by palladium-catalyzed cross-coupling reaction of iodopyrimidines with Zn(CN)2 in very good yields. The cyano group was converted into the corresponding acyl groups by the treatment with Grignard reagents and transformed to amido and imido function as well.