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Paper | Regular issue | Vol 71, No. 4, 2007, pp.911-918
Published online, 23rd February, 2007
DOI: 10.3987/COM-07-11003
Chemoselective Oxidation of 6-Hydroxyalkylpteridine and Its Application to Synthesis of 6-Acyl-7,8-dihydropteridine

Sudhir S. Landge, Kazunari Kudoh, Yuri Yamada, and Shizuaki Murata*

*Graduate School of Environmental Studies, Nagoya University, Chikusa Nagoya 464-8601 Japan


Alcohol-selective oxidation of 6-1’-hydroxyalkylpteridines catalyzed by ruthenium (IV), RuO4-, gives 6-acylpteridines in high yields. Partial reduction of the products affords 6-acyl-7,8-dihydropteridine derivatives, such as a lipophilic derivative of sepiapterin, deoxysepiapterin, and sepiapterin-C.