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Paper | Regular issue | Vol 71, No. 4, 2007, pp.891-902
Published online, 21st February, 2007
DOI: 10.3987/COM-07-11001
Synthesis of Mexiletine Analogues from Non-Activated Aziridines

Truls Ingebrigtsen and Tore Lejon*

*Faculty of Science, Department of Chemistry, University of Tromsø, N-9037 Tromsø, Norway

Abstract

A general method for the synthesis of mexiletine analogues by nucleophilic ring opening of non-activated racemic aziridines has been developed (Scheme 1). Structural variation is introduced by employing different nucleophiles or by altering the substitution on the aziridine ring.