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Paper | Regular issue | Vol 71, No. 5, 2007, pp.1067-1073
Published online, 9th March, 2007
DOI: 10.3987/COM-07-10992
Cassane and Norcassane Diterpenoids of Caesalpinia bonduc

Joy S. Roach, Stewart McLean, William F. Reynolds, and Winston F. Tinto*

*Laboroatory of Bioorganic Chemistry, Department of Biological and Chemical Sciences, University of the West Indies, Cave Hill Campus, P. O. Box 64, Bridgetown, Barbados, BB11000, West Indies

Abstract

Two new cassane and one norcassane diterpenoid (1-3) were isolated from Caesalpinia bonduc along with caesaldekarins C (4) and F (5). During acquisition of NMR spectral data on compound 5, it rearranged to produce compounds 7 and 8, via compound 6. The 1H and 13C NMR spectra of all compounds were completely assigned using a combination of 2D NMR experiments, including 1H-1H COSY, HSQC, HMBC, and T-ROESY sequences. Compounds 4 and 5 showed modest cytotoxic activity.