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Communication | Special issue | Vol 70, No. 1, 2006, pp.45-50
Published online, 26th September, 2006
DOI: 10.3987/COM-06-S(W)7
Synthesis of Substituted 4-Arylpiperidin-2-ones by a 6-exo-Trig Radical Cyclization

Xavier Vila and Samir Z. Zard*

*Laboratoire de Synthèse Organique Associé au C.N.R.S., Ecole Polytechnique, F-91128 Palaiseau, France


A series of 5-substituted-4-arylpiperidin-2-ones have been synthesized in a 4 step sequence involving a radical 6-exo-trig cyclization as the key step.