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Note | Special issue | Vol 70, No. 1, 2006, pp.541-548
Published online, 11th July, 2006
DOI: 10.3987/COM-06-S(W)6
Chiral Synthesis of Poison-Frog Alkaloids 251N and 221K

Naoki Toyoooka,* Zhou Dejun, Hideo Nemoto,* H. Martin Garraffo, Thomas F. Spande, and John W. Daly

*Faculty of Pharmaceutical Sciences, Toyama University, 2630 Sugitani, Toyama, Toyama 930-0194, Japan


The chiral synthesis of 8-butyl 5-substituted poison-frog alkaloids 251N and 221K has been achieved, and the relative stereochemistry of natural 251N was determined by the present chiral synthesis.