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Communication | Special issue | Vol 70, No. 1, 2006, pp.181-184
Published online, 17th November, 2006
DOI: 10.3987/COM-06-S(W)59
A Convenient Synthesis of 2-Functionalized Pyrrolo[2,3-d]pyrido[1,2-a]pyrimidines

Yuchi Zhang, Keisuke Kawashima, and Michihiko Noguchi*

*Department of Industrial Chemistry, Faculty of Engineering, Yamaguchi University, 2-16-1 Tokiwadai, Ube, Yamaguchi 755-8611, Japan


The thermal reaction of N-benzyl-N-{3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl}amino esters (1) provides 2-substituted pyrrolo[2.3-d]pyrido[1,2-a]pyrimidin-4(1H)-ones (2) effectively. Therein, the lactonization and consecutive decarboxylation of the initially formed methyl 2-substituted 1,2,3,4-dihydro-3-hydroxy-4-oxopyrrolo[2.3-d]pyrido[1,2-a]pyrimidine-2-carboxylates (4) is proposed for the formation of 2.