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Paper | Special issue | Vol 70, No. 1, 2006, pp.477-490
Published online, 2nd November, 2006
DOI: 10.3987/COM-06-S(W)47
Synthesis of 1,2,3,4,5,6,7,10-Octahydro-1,5-imino-7,10-dioxo-3-benzazocine-4-carbonitrile Derivative and Evaluation of Antitumor Activity Related to Saframycin and Renieramycin Isoquinolinequinones

Yu-ichi Koizumi, Ken-ichi Inamura, Akinori Kubo, and Naoki Saito*

*Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan


3-Benzyl-1,2,3,4,5,6,7,10-octahydro-9-methoxy-8,11-dimethyl-7,10- dioxo-1,5-imino-3-benzazocine-4-carbonitrile (4) as a simple model of saframycin A and renieramycin M is prepared and its cytotoxicity tested against three human cancer cell lines.