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Communication | Special issue | Vol 70, No. 1, 2006, pp.143-146
Published online, 21st November, 2006
DOI: 10.3987/COM-06-S(W)43
An Approach to Cyclic α-Amino Acids by a Novel Hetero Diels-Alder/Intramolecular Hydantoin Enolate Alkylation Strategy: An Approach to Halichlorine

Hyoungsu Kim, Jae Hong Seo, Kye Jung Shin, Dong Jin Kim, and Deukjoon Kim*

*College of Pharmacy, Seoul National University, Shillim-Dong, San 56-1, Kwanak-Gu, Seoul 151-742, Korea

Abstract

An efficient, novel synthetic strategy has been developed for preparation of cyclic α-amino acid employing an intermolecular hetero Diels-Alder reaction and an intramolecular hydantoin enolate alkylation as key steps. Application of the present hetero Diels-Alder/intramolecular hydantoin alkylation methodology to synthesis of halichlorine was explored.