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Note | Special issue | Vol 70, No. 1, 2006, pp.581-586
Published online, 29th September, 2006
DOI: 10.3987/COM-06-S(W)27
One-Step Syntesis of 4,5-Disubstituted Pyrimidines Using Commercially Available and Inexpensive Reagents

Phil S. Baran,* Ryan A. Shenvi, and Steven A. Nguyen

*Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, BCC-169, La Jolla, CA 92037, U.S.A.

Abstract

4,5-Disubstituted pyrimidines are synthesized from the corresponding ketone in one-step using inexpensive reagents (formamidine acetate, n-propanol, heat). Contrasted to other methods, this process appears quite amenable to large-scale use in industrial settings.