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Paper | Special issue | Vol 69, No. 1, 2006, pp.231-237
Published online, 1st August, 2006
DOI: 10.3987/COM-06-S(O)20
■ Further Structure-Activity Relationships of the Myxobacterial Antibiotics Cystothiazoles

Bangi A. Kundim, Jianhua Qi, Ryosuke Fudou, Shigeru Yamanaka, and Makoto Ojika*

*Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan

Abstract

Eight derivatives of the bithiazole-type myxobacterial antibiotic cystothiazole A were evaluated for antifungal activity against a phytopathogenic microorganism for a further structure-activity relationship. Two of them, an acetate and a fully conjugated non-chiral derivative, were new derivatives obtained by chemical derivatization of cystothiazole C. The results confirmed the importance of the bend conformation at C-4/C-5, the methyl ether at C-5, and the lipophilicity of the terminal alkyl group of the molecule.