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Paper | Regular issue | Vol 71, No. 3, 2007, pp.647-656
Published online, 30th January, 2007
DOI: 10.3987/COM-06-10977
Synthesis and Cytostatic Evaluation of Pyridopyrimidobenzimidazole Derivatives

Kristina Starcevic, Marijeta Kralj, Katja Ester, and Grace Karminski-Zamola*

*Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, Marulicev trg 20, HR-10000 Zagreb, Croatia


A set of novel 2,5-substituted benzimidazoles (1-7) and their cyclic derivatives (8-11) were synthesized and evaluated for their potential cytostatic effect on various tumor cell lines. The structures of the synthesized compounds were proved by means of IR, 1H NMR and MS spectral data. Based on presented in vitro screening results we may conclude that cyclic compounds bearing nitro and amino substituents (10 and 11) showed the most pronounced growth inhibitory.