Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 71, No. 3, 2007, pp.619-626
Published online, 26th January, 2007
DOI: 10.3987/COM-06-10971
A New One-Step Synthesis of 1,2,4-Triazino[2,3-c]quinazolines

Oleksandr V. Karpenko,* Sergiy I. Kovalenko, Oleksiy O. Chekotylo, and Svitlana V. Shishkina

*Department of Pharmaceutical Chemistry, Zaporizhzhia State Medical University, prosp. Mayakovskogo 26, Zaporizhzhia, 69035, Ukraine


A new and efficient one-step protocol for the synthesis of 3-substituted 2H-1,2,4-triazino[2,3-c]quinazolin-2-ones (5) was developed starting from 4-hydrazinoquinazoline (1) and α-ketocarboxylic acids and their esters. Corresponding hydrazones (2a,c and 3a,c,e) were isolated as intermediate products. Further cyclocondensation followed by acid-catalyzed Dimroth rearrangement resulted in the title derivatives 5.