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Paper | Regular issue | Vol 71, No. 4, 2007, pp.805-814
Published online, 13th February, 2007
DOI: 10.3987/COM-06-10948
Aluminum Dodecatungstophosphate Promoted Synthesis of 1,5-Benzodiazepine Derivatives under Solvent-Free Conditions

Razieh Fazaeli,* Hamid Aliyan,* and Shahram Tangestaninejad

*Department of Chemistry, Islamic Azad University, Shahreza branch, 86145-311, Iran


Solid heteropoly acids (AlTP and AlMP) are easily used as efficient catalyst for conversion of o-phenylenediamines and ketones to their corresponding 2,3-dihydro-1H-1,5-benzodiazepines at room temperature under solvent-free conditions. The method is an easy, rapid, and high yielding reaction for the synthesis of 1,5-benzodiazepine derivatives and is applicable to both cyclic or acyclic ketones without significant difference.