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Note | Regular issue | Vol 71, No. 2, 2007, pp.453-458
Published online, 22nd December, 2006
DOI: 10.3987/COM-06-10945
Expeditious Entry to 1,5-Benzodiazepines Catalyzed by Sulfamic Acid at Room Temperature in Tap Water Suspension

Zhenjiang Li,* Yingjie Sun, Xinghua Ren, Yuhu Shi, and Pingkai Ouyang

*College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, 5, Xinmofan Malu, Nanjing 210009, China


2,3-Dihydro-1H-1,5-benzodiazepines have been synthesized in tap water suspension as well as in neat condition in good to excellent yield from direct condensations of o-phenylenediamines with ketones promoted by sulfamic acid at room temperature.