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Communication | Regular issue | Vol 68, No. 12, 2006, pp.2465-2469
Published online, 27th October, 2006
DOI: 10.3987/COM-06-10889
Synthesis of Octahydropyrrolo[3,2-c]pyridine Derivatives by the Catalytic Asymmetric Intramolecular Cycloaddition of Azomethine Ylides

Yoji Oderaotoshi,* Hiroyuki Miyata, Satoshi Minakata, and Mitsuo Komatsu*

*Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 560-0871, Japan


The synthesis of optically active octahydropyrrolo[3,2-c]pyridine derivatives was achieved via the asymmetric intramolecular cycloaddition of azomethine ylides using copper-bisphosphine complexes. Cu(OTf)2-(R,R)-CHIRAPHOS is a suitable catalyst for the reactions.