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Paper | Regular issue | Vol 68, No. 11, 2006, pp.2365-2373
Published online, 29th September, 2006
DOI: 10.3987/COM-06-10874
Synthesis of Pipecolic Acid and Baikiain

Meng-Yang Chang,* Yung-Hua Kung, and Tsun-Cheng Wu

*Department of Applied Chemistry, National University of Kaohsiung, Kaohsiung 811, Taiwan, R.O.C.


A straightforward synthesis of pipecolic acid and baikiain was achieved from trans-(2S,4R)-4-hydroxyproline via the key steps of regioselective Baeyer-Villiger reaction and ring-closing metathesis.