Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 71, No. 1, 2007, pp.1-4
Published online, 1st December, 2006
DOI: 10.3987/COM-06-10873
Synthetic Models Related to Furanocoumarin-CYP 3A4 Interactions. Synthesis of Furanocoumarin Derivatives as Potent Inhibitors of CYP 3A4

Kazuaki Oda,* Yukio Tamai, Yuki Yamaguchi, Teruki Yoshimura, Keiji Wada, Minoru Machida, and Naozumi Nishizono*

*Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan


We prepared a series of furanocoumarin derivatives that have inhibitory effects on the activity of human cytochrome P450 (CYP) 3A4. The reported furanocoumarin dimers paradisins A and B from grapefruit juice showed potent CYP 3A4 inhibition with an IC50 value of 0.07 μM. Synthetic furanocoumarin derivatives, which are more stable and accessible than paradisins, exhibited comparable activity against CYP 3A4.