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Paper | Regular issue | Vol 68, No. 10, 2006, pp.2097-2106
Published online, 22nd August, 2006
DOI: 10.3987/COM-06-10829
Mucoralactone A: An Unusual Steroid from the Liquid Culture of Mucor plumbeus

Athar Ata,* Leigha J. Conci, and Ilkay Orhan

*Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, R3B 2E9, Canada

Abstract

Mucoralactone A (1), a novel steroid, was isolated from the liquid culture of Mucor plumbeus. Its structure was elucidated with the aid of extensive spectroscopic studies. Mucoralactone A (1) has a lactone moiety incorporated in its structure, and exhibited acetylcholinesterase enzyme inhibition activity with an IC50 value of 19 μM and modest antifungal activity against Candida albicans.