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Paper | Regular issue | Vol 68, No. 10, 2006, pp.2079-2086
Published online, 1st August, 2006
DOI: 10.3987/COM-06-10825
Synthesis of Enantiopure 3,5-Disubstituted Pyrrolidines by Ring-Opening/Cross-Metathesis Reaction of 2-Azanorbornene Derivatives

Odón Arjona,* Ma José Cabas, José Nieto-Rubio, and Ana Querejeta

*Department of Organic Chemistry, Faculty of Chemistry, Complutense University, E-28040, Madrid, Spain


A concise method for the synthesis of enantiopure 3,5-disubstituted pyrrolidines from 2-azanorbornene derivatives is described. The method is also applied to the synthesis of 3,5-disubstituted prolines.