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Communication | Regular issue | Vol 68, No. 8, 2006, pp.1559-1564
Published online, 23rd June, 2006
DOI: 10.3987/COM-06-10762
A Facile and Convenient Synthesis of 1H-Isoindole-1,3(2H)-diones

Farzad Nikpour,* Samira Kazemi, and Davood Sheikh

*Department of Chemistry, Faculty of Sciences, University of Kurdistan, Sanandaj, Pasdaran Bivd., P.O.Box 66135-416, Iran

Abstract

A facile synthesis of 1H-isoindole-1,3(2H)-diones (3a-h) has been developed by the reaction of the corresponding anhydrides (1a-h) with potassium cyanate (4a) or sodium thiocyanate (4b). The reactions were carried out in neutral media under reflux or under microwave irradiation without use of catalyst. Good to excellent yields of the products were obtained in high purity with very simple work-up.