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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Note | Regular issue | Vol 68, No. 4, 2006, pp.837-840
Published online, 10th March, 2006■ Methylation of Non-acidic Alcohols of Alkaloids with TMS-diazomethane: Conversion of Codeine to Codeine-6-methyl Ether
Published online, 10th March, 2006
DOI: 10.3987/COM-06-10694
■ Methylation of Non-acidic Alcohols of Alkaloids with TMS-diazomethane: Conversion of Codeine to Codeine-6-methyl Ether
Christopher W. Cunningham, Linn N. Thatcher, and Andrew Coop*
*Department of Pharmceutcial Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, Baltimore, MD 21201, U.S.A.
Abstract
Trimethylsilyldiazomethane (TMS-CHN2) is a convenient agent for the methylation of acidic alcohols, and is known to methylate non-acidic alcohols in CH2Cl2 by the addition of HBF4. Herein, we show that silica gel acts as a suitable alternative for alkaloids, without causing precipitation of the salt from the reaction mixture.
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