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Paper | Regular issue | Vol 68, No. 4, 2006, pp.721-732
Published online, 3rd March, 2006
DOI: 10.3987/COM-06-10675
Synthesis of Peptidomimetic Analogues of Echinocandins

Chao-Mei Ma, Sunao Takeda, Satoshi Hibino, and Mohsen Daneshtalab*

*School of Pharmacy, Memorial University of Newfoundland, St. John’s, NL, A1B 3V6, Canada


Novel peptidomimetic compounds with partial structures being the same as that of echinocandin B, a well known antifungal lipopeptide, have been synthesized. The structures of these compounds were confirmed by NMR and MS. The synthesized compounds were tested for their in vitro antifungal activity. The results suggested that the hydroxyproline-threonine section in the north-western position of the echinocadin is important for the activity.