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■ Synthesis of Cribrostatin 6 and Its Related Compounds

Shinsuke Nakahara,* Akinori Kubo, Yuzuru Mikami,* and Junji Ito

*Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

Abstract

The synthesis of cribrostatin 6 (1), which shows good biological activity as a dark blue cancer cells growth inhibitor and a number of pathogenic bacteria and fungi, was achieved in two steps from 1-acetylaminomethyl-5,7-diethoxy-8-hydroxy-6-methylisoquinoline (14). The related compounds (8~11) were also synthesized, and the antimicrobial activities of 1 and its nine related compounds (5~13) were investigated.