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Note | Regular issue | Vol 68, No. 3, 2006, pp.549-559
Published online, 21st February, 2006
DOI: 10.3987/COM-06-10668
High-yielding Microwave Assisted Synthesis of Quinoline and Dihydroquinoline Derivatives under Solvent-free Conditions

D. Subhas Bose* and Racherla Kishore Kumar

*Organic Chemistry Division III, Fine Chemicals Laboratory, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India


A mild and efficient solvent-free method has been developed by two different approaches for the synthesis of quinoline and dihydroquinoline derivatives: (i) one-pot reaction of anilines with alkyl vinyl ketones (Skraup reaction) (ii) between various acetophenones and 2-aminoacetophenone (Friedländer reaction) using stable and effective heterogeneous catalyst potassium dodecatangestocobaltate (25 mol %) (PDTC) under microwave irradiation in high yields.