Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 67, No. 2, 2006, pp.549-554
Published online, 14th October, 2005
DOI: 10.3987/COM-05-S(T)65
Synthesis of 3-Oxoazacyclohept-4-enes by Ring-closing Metathesis. Application to the Synthesis of an Inhibitor of Cathepsin K

Catherine Taillier, Thomas Hameury, Véronique Bellosta,* and Janine Cossy*

*Laboratoire de Chemie Organique, Ecole Supérieure de Physique & Chemie Industrielle, 10 rue Vauquelin, 75231 Paris Cedex 05, France


The ring-closing metathesis allows the formation of 3-oxoazacyclohept-4-enes from but-3-enamine. By using this methodology, the synthesis of an inhibitor of cathepsin K was achieved in 10 steps from but-3-enamine.