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Paper | Special issue | Vol 67, No. 2, 2006, pp.695-704
Published online, 16th September, 2005
DOI: 10.3987/COM-05-S(T)61
Construction of Optically Active Spiroketal by Direct Aldol Reaction

Hisanaka Ito,* Chie Kawabe, and Kazuo Iguchi*

*Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


Novel preparation of symmetric spiroketal was developed by the use of direct aldol reaction of α-hydroxyacetophenone catalyzed by chiral dinuclear zinc catalyst. The spiroketal was obtained in excellent enantiomeric excess.