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Communication | Special issue | Vol 67, No. 1, 2006, pp.129-134
Published online, 13th September, 2005
DOI: 10.3987/COM-05-S(T)57
Synthesis of Optically Active Methyl 1,2,3,3a,8,8a-Hexahydropyrrolo[2,3-b]indole-2-carboxylates Having a Halogen or an Oxygen Functional Group at the 3a-Position

Fumio Yamada, Yoshikazu Fukui, Takako Iwaki, Sachiko Ogasawara, Masaki Okigawa, Satomi Tanaka, and Masanori Somei*

*Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan

Abstract

A simple and new method for the preparation of optically active methyl 3a-chloro-, 3a-bromo-, 3a-hydroxy-, and 3a-alkoxy-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylates has been developed.