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Note | Special issue | Vol 67, No. 2, 2006, pp.769-775
Published online, 18th October, 2005
DOI: 10.3987/COM-05-S(T)45
Facile Preparation of Substituted Benzimidazole-2-carboxylates

Yongbao Zhu, Krystyna A. Skupinska, and Ernest J. McEachern*

*Department of Chemistry, AnorMED, Inc., #200-20353 64th Ave., Langley, B. C., V2Y 1N5, Canada


Mild conditions for the preparation of benzimidazole-2-carboxylates have been developed. Condensation of a substituted 1,2-phenylenediamine with methyl trichloroacetamidate in the presence of TFA rapidly affords the 2-trichloromethylbenzimidazole; hydrolysis provides the desired product.