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Communication | Special issue | Vol 67, No. 1, 2006, pp.113-117
Published online, 6th September, 2005
DOI: 10.3987/COM-05-S(T)34
The Mannich-type Reaction between N,O-Acetals and Carbon Nucleophiles under Solvent-free Conditions

Yoshihiro Matsumura,* Takashi Ikeda, and Osamu Onomura

*School of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan


The Mannich-type reaction for 1-methoxycarbonyl- or 1-benzyloxycarbonyl-2-methoxylpyrrolidine with carbon nucleophiles such as acetylacetone, methyl acetoacetate, dimethyl malonates, benzoylacetone, dibenzoylmethane, or cyclohexane-1, 3-dione proceeded by acid catalysis under solvent-free conditions with more efficiency than that in dichloromethane.