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Communication | Special issue | Vol 67, No. 2, 2006, pp.489-494
Published online, 28th October, 2005
DOI: 10.3987/COM-05-S(T)17
Synthesis of 5-Heterocyclic Substituted Quinazolin-4-ones via 2-Aminobenzonitrile Derivatives

M. Jonathan Fray,* Paul Allen, Paul R. Bradley, Clare E. Challenger, Michael Closier, Tim J. Evans, Mark L. Lewis, John P. Mathias, Carly L. Nichols, Yvonne M. Po-Ba, Hayley Snow, Mark H. Stefaniak, and Hannah V. Vuong

*Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent, CT13 9NJ, U.K.


Two routes to prepare a series of six 5-heterocyclic substituted 2-chloro-7-methoxyquinazolin-4-ones are described, where the heterocycle is a substituted or unsubstituted 1-pyrazolyl, 5-pyrazolyl or 2-thiazolyl group. Both routes proceeded via key 2-aminobenzonitrile intermediates.