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Note | Regular issue | Vol 68, No. 4, 2006, pp.779-785
Published online, 3rd March, 2006
DOI: 10.3987/COM-05-10649
New Derivatives of 3-[(4-Phenyl-5-oxo-1,2,4-triazolin-1-yl)methyl]-4-substituted 1,2,4-Triazolin-5-one

Monika Wujec, Monika Pitucha, and Maria Dobosz*

*Department of Organic Chemistry, Faculty of Pharmacy, Medical University in Lublin, 6 Staszica Str., 20-081 Lublin, Poland


In the reaction of hydrazide of (4-phenyl-5-oxo-1,2,4-triazolin-1-yl)acetic acid (1) with isocyanate the respective semicarbazide derivatives (2) were obtained. Further cyclization with 2% NaOH led to the formation of [3-(4-phenyl-5-oxo-1,2,4-triazolin-1-yl)methyl]-4-substituted 1,2,4-triazolin-5-one (3) and (4-phenyl-5-oxo-1,2,4-triazolin-1-yl)acetic acid (4).