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Note | Regular issue | Vol 68, No. 2, 2006, pp.387-393
Published online, 17th January, 2006
DOI: 10.3987/COM-05-10645
A Synthesis of N-Formylenamides of Isoquinoline

Iliyan Ivanov,* Stoyanka Nikolova, Stela Statkova-Abeghe, and Plamen Angelov

*Department of Organic Chemistry, University of Plovdiv, 24, Tsar Assen Str. 4000 Plovdiv, Bulgaria


N-Formylenamides of isoquinoline (6) were obtained from N-[2-(2-acyl-4,5-dimethoxyphenyl)ethyl]formamides (5) by cyclization in the presence of catalytic amount of p-toluensulfonic acid. The starting keto formamides (5) were obtained by acylation of a N-[2-(3,4-dimethoxyphenyl)ethyl]formamides (1) with carboxylic acids or their anhydrides in polyphosphoric acid (PPA).