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Note | Regular issue | Vol 68, No. 2, 2006, pp.375-380
Published online, 13th January, 2006
DOI: 10.3987/COM-05-10628
Microwave-assisted Gewald Synthesis of 2-Aminothiophenes Using Functional Ionic Liquid as Soluble Support

Yi Hu,* Ping Wei, He Huang, Shi-Qing Han, and Ping-Kai Ouyang*

*College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China


A microwave-assisted liquid-phase Gewald synthesis of 2-aminothiophenes was developed using task-specific ionic liquid—[2-hydemim][BF4] as soluble support. This new synthetic method is simple and efficient, and the products are obtained in good to excellent yields with high purities, without the need for chromatographic purification.