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■ Shimalactones, Neuritogenic Polyketides from a Marine-derived Fungus Emericella variecolor GF10

Hong Wei, Takuya Itoh, Naoyuki Kotoku, and Motomasa Kobayashi*

*Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Toyonaka, Osaka 560-0043, Japan

Abstract

Shimalactone B (2), a novel polyketide having bicyclo[4.2.0]octadiene and oxabicyclo[2.2.1]heptane units, was isolated as a minor constituent from a cultured marine-derived fungus of Emericella variecolor GF10. The chemical structure of 2 and the structural relationship between shimalactones A and B (2) were determined by detailed NMR and CD spectroscopic analyses and chemical derivatization. Shimalactones A and B (2) induced neuritogenesis against neuroblastoma Neuro 2A cells at 10 μg/mL concentration.