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Paper | Regular issue | Vol 65, No. 11, 2005, pp.2721-2728
Published online, 16th September, 2005
DOI: 10.3987/COM-05-10531
Synthesis of 1,2-Disubstituted Imidazoles via Cross-Coupling and Substitution Reactions

Ingo Langhammer and Thomas Erker*

*Department of Medicinal/Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, A-1090 Wien, Austria

Abstract

Lithiation of imidazole compound (1) in position 2 and subsequent quenching with electrophiles provided a route to 1,2-diaryl-, 1-aryl-2-cycloalkyl- and 1-aryl-2-heterocyclyl-substituted imidazoles.