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Note | Regular issue | Vol 65, No. 11, 2005, pp.2771-2776
Published online, 26th August, 2005
DOI: 10.3987/COM-05-10523
New Vermistatin Derivatives Isolated from Penicillium simplicissimum

Shin-ichirou Komai, Tomoo Hosoe, Takeshi Itabashi, Koohei Nozawa, Takashi Yaguchi, Kazutaka Fukushima, and Ken-ichi Kawai*

*Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan


Four new vermistatin derivatives, dihydrovermistatin (1), acetoxy- dihydrovermistatin (2), hydroxydihydrovermistatin (3), and penisimplicissin (4) were isolated along with vermistatin (5), penicillide, and funicone from the extract of Penicillium simplicissimum IFM 53375. The structures of 1 - 4 were determined by spectroscopic and chemical methods.