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Note | Regular issue | Vol 65, No. 12, 2005, pp.2949-2955
Published online, 14th October, 2005
DOI: 10.3987/COM-05-10519
An Efficient Synthesis of New Spiro[indolo-3(1H),2’(3’H)-oxadiazolyl] and 1-(Triazol-4-ylmethyl)isatin Derivatives

Rachid Bouhfid, Nicolas Joly, Mohamed Massoui, Roméo Cecchelli, Vincent Lequart, Patrick Martin,* and El Mokhtar Essassi

*Blood-Brain Barrier Laboratory (EA 2465), IUT of Béthune, University of Artois, BP 819, F-62408 Béthune, France

Abstract

The synthesis and the characterization of new isatin derivatives obtained by 1,3-dipolar cycloaddition reactions on allylisatin and propargylisatin are described. The products thus regiospecifically obtained in good yields bear oxadiazolyles or trizolyles groups, and were characterized by FT-IR spectroscopy, NMR spectroscopy and mass spectrometry.