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Note | Regular issue | Vol 65, No. 12, 2005, pp.2937-2947
Published online, 14th October, 2005
DOI: 10.3987/COM-05-10472
A Convenient Procedure for the Synthesis of Substituted 4-Methylaminocoumarins

Khadeejh H. A. Al-Zghoul, Kifah S. M. Salih, Mikdad T. Ayoub,* and Mohammad S. Mubarak*

*Chemistry Department, Faculty of Science, University of Jordan, Amman, Jordan


3-Bromo-7-methoxy-4-methylcoumarin and 3-bromo-4,7-dimethyl-coumarin give a mixture of the corresponding 3-aminocoumarins and 4-aminomethylcoumarins upon the reaction with a number of secondary amines. In addition, the reaction of 7-methoxy- and 7-methyl-4-bromomethylcoumarins with secondary diamines affords the corresponding N,N`-dicoumarinmethyldiamine.