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Paper | Regular issue | Vol 65, No. 11, 2005, pp.2593-2603
Published online, 19th August, 2005
DOI: 10.3987/COM-05-10469
Palladium-catalysed Synthesis of Pyrimidines

Truls Ingebrigtsen, Irene Helland, and Tore Lejon*

*Faculty of Science, Departmentof Chemistry, University of Tromsø, N-9037 Tromsø, Norway

Abstract

Satisfactory yields of 4-substituted pyrimidines and bicyclic pyrimidines are produced from α-methyl or α-methylene ketones when reacted with formamide and tetrakis(triphenylphosphine)palladium(0) or a 1:2 mixture of palladium(II) acetate and triphenylphosphine as catalysts. Under the same reaction conditions pyridines or imidazole are formed from 1,3- or 1,2-diketones.