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Note | Regular issue | Vol 65, No. 8, 2005, pp.1975-1984
Published online, 8th July, 2005
DOI: 10.3987/COM-05-10445
Synthesis of 2,4-Diarylimidazoles through Suzuki Cross-coupling Reactions of Imidazole Halides with Arylboronic Acids

Ingo Langhammer and Thomas Erker*

*Department of Medicinal/Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, A-1090 Vienna, Austria


The Suzuki coupling, a Pd-catalyzed cross-coupling reaction of a boronic acid with an aryl halide, was used to prepare several 2,4-diarylimidazoles. Iodinated and brominated imidazoles (3) and (9) proved to be suitable aryl halides for Suzuki coupling. These imidazole halides readily reacted with phenyl-, naphthyl- and biphenylboronic acids under Suzuki conditions to give arylated imidazoles.