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Paper | Regular issue | Vol 65, No. 8, 2005, pp.1871-1879
Published online, 20th May, 2005
DOI: 10.3987/COM-05-10428
Synthesis and Antimicrobial Activity of Some New Pyridazine Derivatives

Maria D. Caprosu, Roxana M. Butnariu, and Ionel I. Mangalagiu*

*Department of Organic and Biochemistry, “Al. I. Cuza” University Iasi, 11 Carol I Bd., 700506 Iasi-6, Romania

Abstract

Five new pyridazine derivatives (1 salt and 4 pyrrolopyridazine cycloadducts) were prepared and tested in vitro as antimicrobial compounds. Some of them have proved to have a remarkable activity against different micro organisms (germs and fungi). The influence of microwave irradiation concerning cycloaddition reactions of pyridazinium ylides was studied. Stereo- and regiochemistry involved in these reactions are also discussed.