Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 65, No. 8, 2005, pp.1843-1856
Published online, 17th May, 2005
DOI: 10.3987/COM-05-10425
Selective Reduction of Nitrocinnamoylfumagillols with α,β-Unsaturated Ester Using Borohydride Exchange Resin (BER)-Nickel Acetate

Hong Woo Lee,* Joong Bok Ahn, Jung Hwa Lee, Sung Kwon Kang, Soon Kil Ahn, and Sang Joon Lee

*Chemical Process Development Laboratories, Chong Kun Dang Research Institute, Chonan P.O. Box 74, Chonan, 330-831, Korea


Borohydride Exchange Resin (BER) — nickel acetate system readily reduces nitrocinnamoylfumagillols to the corresponding amines in excellent yields, high chemoselectivity, and simple procedure. Especially, this system tolerates two epoxides (spiro-epoxide and the one on C4 alkene side chain) and the α,β-unsaturated ester moiety at C6 on the fumagillol.