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Paper | Regular issue | Vol 65, No. 8, 2005, pp.1837-1842
Published online, 17th May, 2005
DOI: 10.3987/COM-05-10417
A New α-Glucosidase Inhibiting Dithiadiazetidin Derivative from Symplocos racemosa

Muhammad Athar Abbasi, Viqar Uddin Ahmad,* Muhammad Zubair, Muhammad Abid Rashid, Shamsun Nahar Khan, Umar Farooq, M. Iqbal Choudhary, and Klaus-Peter Zeller

*International Centre for Chemical Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan


The phytochemical investigation of the n-butanol soluble fraction of Symplocos racemosa Roxb. resulted in the isolation of a new dithiadiazetidin derivative; symploate (1). Its structure was established through various 1D and 2D NMR techniques together with high-resolution mass spectrometric techniques and spectral evidences. The symploate (1) showed moderate inhibitory activity against α-glucosidase in a concentration-dependent fashion with an IC50 value of 691.1 ± 3.29 μM.