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Note | Regular issue | Vol 65, No. 7, 2005, pp.1691-1704
Published online, 13th May, 2005
DOI: 10.3987/COM-05-10402
Synthesis of a New Family of Ligands with Bispyrazole Structure. Reactivity of Bispyrazolylmethyl Ethers

Pérez-Mayoral Elena, García-Amo María, López-Larrubia Pilar, Cerdán Sebastián, and Paloma Ballesteros*

*Instituto Universitario de Investigación, UNED, Senda del Rey 9, s/n, E-28040 Madrid, Spain

Abstract

We report the synthesis of a new family of chelating ligands containing bispyrazole structure. Some of them undergo an unusual reactivity when they react with methyl iminodiacetate. We propose a tentative mechanism that probably involves 4-chloromethylpyrazoles and the corresponding alcohols as reaction intermediates. The corresponding Gd-complexes exhibit interesting relaxivity properties being potential paramagnetic contrast agents.