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Paper | Regular issue | Vol 65, No. 7, 2005, pp.1609-1614
Published online, 28th April, 2005
DOI: 10.3987/COM-05-10391
Concise Formal Synthesis of (S)-Gregatin B

Keizo Matsuo,* Masaru Kanayama, Jinyi Xu, Rie Takeuchi, Keiji Nishiwaki, and Yukihiro Asaka

*Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1, Kowakae, Higashi-Osaka 577-8502, Japan


(S)-3-Acetyl-5-[(1E,3E)-1,3-hexadienyl]-4-hydroxy-5-methyl-2(5H)-furanone, known precursor for the synthesis of (S)-gregatin B, was synthesized in a fewer steps and higher overall yield starting from (R)-lactic acid.