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Note | Regular issue | Vol 65, No. 7, 2005, pp.1679-1683
Published online, 13th May, 2005
DOI: 10.3987/COM-05-10388
Synthesis and Characterization of Bisindole-7,7’-dichloro-2,2’-diethoxycarbonyl-5,5’-bis-1H-indole

Zeghough Djidel,* Laib Nouari, Ouali Dehimi, Latelli H’mida, and Saadi Hocine

*Laboratory of Oragnic Synthesis ad Phytochemistry, M’sila University, P.O.Box 859, M’sila 28000, Algeria

Abstract

3,3’-Dichlorobenzidine is used for the preparation of 7,7’- dichloro-2,2’-diethoxycarbonyl-5,5’-bis-1H-indole. This was accomplished by converting the diamine to the diazonium salts. Reduction of this diazonium salts afforded dihydrazine which was condensed with ethyl pyruvate to give dihydrazone that is separated on column chromatography to provide the following isomers: syn-syn, syn-anti and anti-anti. Cyclization of the dihydrazone using polyphosphate ester gave 7,7’-dichloro-2,2’- diethoxycarbonyl- 5,5’- bis-1H-indole.