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Note | Regular issue | Vol 65, No. 7, 2005, pp.1673-1678
Published online, 13th May, 2005
DOI: 10.3987/COM-05-10386
A Convenient New Synthesis of 1,2-Diarylpyrroles from 3-Ethoxycarbonyl-4-oxo-4-phenylbutyraldehyde

Aurélie Delayen, Laurence Goossens, Raymond Houssin, and Jean-Pierre Hénichart*

*Institut de Chimie Pharmaceutique, Albert Lespagnol, Université de Lille 2, 3, rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France

Abstract

An efficient four-step synthesis of ethyl 1,2-diaryl-3-pyrrole carboxylates (4), an isomeric scaffold of pharmacologically active natural products, is reported. The key synthon 3-ethoxycarbonyl-4-oxo-4-phenylbutyraldehyde (3), whose new synthesis is detailed here, reacts conveniently with anilines to create the pyrrole ring.